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Estimation of a Multi-fascicle Model from Single B-Value Data with a Population-Informed Prior*
Maxime Taquet1, 2, Benoît Scherrer1, Nicolas Boumal2, Benoît Macq2, and Simon K. Warfield1
1Computational Radiology Laboratory, Harvard Medical School, Boston, USA
2ICTEAM Institute, Université catholique de Louvain, Louvain-la-Neuve, Belgium
Abstract. Diffusion tensor imaging cannot represent heterogeneous fascicle orientations in one voxel. Various models propose to overcome this limitation. Among them, multi-fascicle models are of great interest to characterize and compare white matter properties. However, existing methods fail to estimate their parameters from conventional diffusion sequences with the desired accuracy. In this paper, we provide a geometric explanation to this problem. We demonstrate that there is a manifold of indistinguishable multi-fascicle models for single-shell data, and that the manifolds for different b-values intersect tangentially at the true underlying model making the estimation very sensitive to noise. To regularize it, we propose to learn a prior over the model parameters from data acquired at several b-values in an external population of subjects. We show that this population-informed prior enables for the first time accurate estimation of multi-fascicle models from single-shell data as commonly acquired in clinical context. The approach is validated on synthetic and in vivo data of healthy subjects and patients with autism. We apply it in population studies of the white matter microstructure in autism spectrum disorder. This approach enables novel investigations from large existing DWI datasets in normal development and in disease.
Keywords: Diffusion, Single-Shell, Generative Models, Estimation
*MT and NB are research fellows of the F.R.S.-FNRS. MT is also research fellow of the B.A.E.F. This work was supported in part by NIH grants 1U01NS082320, R01 EB008015, R03 EB008680, R01 LM010033, R01 EB013248, P30 HD018655, BCH TRP, R42 MH086984 and UL1 TR000170.
LNCS 8149, p. 695 ff.
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© Springer-Verlag Berlin Heidelberg 2013