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Learning to Segment Neurons with Non-local Quality Measures
Thorben Kroeger1, Shawn Mikula2, Winfried Denk2, Ullrich Koethe1, and Fred A. Hamprecht1
1HCI, University of Heidelberg, Germany
2MPI for Medical Research, Heidelberg, Germany
Abstract. Segmentation schemes such as hierarchical region merging or correllation clustering rely on edge weights between adjacent (super-)voxels. The quality of these edge weights directly affects the quality of the resulting segmentations. Unstructured learning methods seek to minimize the classification error on individual edges. This ignores that a few local mistakes (tiny boundary gaps) can cause catastrophic global segmentation errors. Boundary evidence learning should therefore optimize structured quality criteria such as Rand Error or Variation of Information. We present the first structured learning scheme using a structured loss function; and we introduce a new hierarchical scheme that allows to approximately solve the NP hard prediction problem even for huge volume images. The value of these contributions is demonstrated on two challenging neural circuit reconstruction problems in serial sectioning electron microscopic images with billions of voxels. Our contributions lead to a partitioning quality that improves over the current state of the art.
LNCS 8150, p. 419 ff.
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© Springer-Verlag Berlin Heidelberg 2013