Murat

Murat Bilgel

Image Analysis and Communications Laboratory, Johns Hopkins University
Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health

Contact Information

Email: mbilgel1@jhmi.edu

Education

• Ph.D., Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 2011 - 2016
  
• B.S., Biomedical Engineering, Johns Hopkins University School of Engineering, Baltimore, MD, 2007 - 2011
  
• IB Diploma, Armand Hammer United World College of the American West, Montezuma, NM, 2005 - 2007
  

Honors and Awards

• Pre-doctoral Intramural Research Training Award, National Institutes of Health, Fall 2012 - 2016
  
• Fellows Award for Research Excellence, National Institutes of Health, Summer 2015
  
• Alzheimer's Association International Conference Travel Fellowship, Summer 2015
  
• Human Amyloid Imaging Young Investigator Travel Scholarship, Winter 2014-5
  
• Graduate Student Association Travel Award, Johns Hopkins University School of Medicine, Spring 2013
  
• Member, Tau Beta Pi National Engineering Honor Society
  
• Richard J. Jones Award For Outstanding Academic Achievement, Johns Hopkins University School of Engineering, Spring 2011
  

Publications

Journal Articles

• M. Bilgel, J. L. Prince, D. F. Wong, S. M. Resnick, B. M. Jedynak, "A multivariate nonlinear mixed effects model for longitudinal image analysis: Application to amyloid imaging", NeuroImage, [in press]. (doi)
• S. Roy, A. Carass, J. Pacheco, M.Bilgel, S. M. Resnick, J. L. Prince, D. L. Pham, "Temporal filtering of longitudinal brain magnetic resonance images for consistent segmentation", NeuroImage: Clinical, 11:264-275, 2016. (doi)
• M.Bilgel, Y. An, Y. Zhou, D. F. Wong, J. L. Prince, L. Ferrucci, S. M. Resnick, "Individual estimates of age at detectable amyloid onset for risk factor assessment", Alzheimer's & Dementia, [in press].
• M. Thambisetty, Y. Chuang, Y. An, M. Bilgel, D. Wong, J. Troncoso, R. O'Brien, J. Breitner, L. Ferrucci, S. Resnick, "Midlife adiposity predicts earlier onset of Alzheimer's dementia, neuropathology and presymptomatic cerebral amyloid accumulation", Molecular Psychiatry, [epub ahead of print]. (doi)
• M. Bilgel, A. Carass, S. M. Resnick, D. F. Wong, J. L. Prince, "Deformation field correction for spatial normalization of PET images", NeuroImage, 119(1):152-163, October 2015. (doi)
• J. Sojkova, J. Goh, M. Bilgel, B. Landman, X. Yang, Y. Zhou, Y. An, L. L. Beason-Held, M. A. Kraut, D. F. Wong, S. M. Resnick, "Voxel-wise relationships between distribution volume ratio and cerebral blood flow: implications for analysis of β-amyloid images", Journal of Nuclear Medicine, 56(7):1042-1047, July 2015. (doi)
• S. M. Resnick, M. Bilgel, A. Moghekar, A. Yang, Q. Cai, M. Wang, M. Thambisetty, J. L. Prince, Y. Zhou, A. Soldan, D. F. Wong, R. J. O'Brien, L. Ferrucci, M. S. Albert, "Changes in Aβ biomarkers and associations with APOE genotype in two longitudinal cohorts", Neurobiology of Aging, 36(8):2333-2339, August 2014. (doi)
• P. A. Nyquist, M. Bilgel, R. Gottesman, L. R. Yanek, T. F. Moy, L. C. Becker, J. L. Cuzzocreo, J. Prince, B. A. Wasserman, D. M. Yousem, D. M. Becker, B. G. Kral, D. Vaidya, "Age differences in periventricular and deep white matter lesions", Neurobiology of Aging, 36(4):1653-1658, April 2015. (doi)
• P. A. Nyquist, L. R. Yanek, M. Bilgel, J. Cuzzocreo, L. C. Becker, K. Chevalier-Davis, D. Yousem, J. Prince, B. G. Kral, D. Vaidya, D. M. Becker, "Effect of white matter lesions on manual dexterity in healthy middle-aged persons", Neurology, 84(19):1920-1926, May 2015. (doi)
• M. Bilgel, Y. An, A. Lang, J. Prince, L. Ferrucci, B. Jedynak, S. M. Resnick, "Trajectories of Alzheimer disease-related cognitive measures in a longitudinal sample", Alzheimer’s & Dementia, 10(6):735-742, November 2014. (doi)
• N. Annaluru, H. Muller, L. A. Mitchell, S. Ramalingam, G. Stracquadanio, S. M. Richardson, J. S. Dymond, Z. Kuang, L. Z. Scheifele, E. M. Cooper, Y. Cai, K. Zeller, N. Agmon, J. S. Han, M. Hadjithomas, J. Tullman, K. Caravelli, K. Cirelli, Z. Guo, V. London, A. Yeluru, S. Murugan, K. Kandavelou, N. Agier, G. Fischer, K. Yang, J. A. Martin, M. Bilgel, P. Bohutski, K. M. Boulier, B. J. Capaldo, J. Chang, K. Charoen, W. J. Choi, P. Deng, J. E. DiCarlo, J. Doong, J. Dunn, J. I. Feinberg, C. Fernandez, C. E. Floria, D. Gladowski, P. Hadidi, I. Ishizuka, J. Jabbari, C. Y. L. Lau, P. A. Lee, S. Li, D. Lin, M. E. Linder, J. Ling, J. Liu, J. Liu, M. London, H. Ma, J. Mao, J. E. McDade, A. McMillan, A. M. Moore, W. C. Oh, Y. Ouyang, R. Patel, M. Paul, L. C. Paulsen, J. Qiu, A. Rhee, M. G. Rubashkin, I. Y. Soh, N. E. Sotuyo, V. Srinivas, A. Suarez, A. Wong, R. Wong, W. R. Xie, Y. Xu, A. T. Yu, R. Koszul, J. S. Bader, J. D. Boeke, S. Chandrasegaran, "Total synthesis of a functional designer eukaryotic chromosome", Science, 344(6179):55-58, 4 April 2014. (doi)
• P. A. Nyquist, M. Bilgel, R. Gottesman, L. R. Yanek, T. F. Moy, L. C. Becker, J. Cuzzocreo, J. Prince, D. M. Yousem, D. M. Becker, B. G. Kral, D. Vaidya, "Extreme deep white matter hyperintensity volumes are associated with African American race", Cerebrovasc. Dis., 37(4):244-250, Mar 2014. (doi)
• A. P. Spira, A. A. Gamaldo, Y. An, M. N. Wu, E. M. Simonsick, M. Bilgel, Y. Zhou, D. F. Wong, L. Ferrucci, S. M. Resnick, "Self-reported Sleep and β-Amyloid Deposition in Community-Dwelling Older Adults", JAMA Neurology, 70(12):1537-1543, December 2013. (doi)

Conference Papers

• M. Bilgel, B. Jedynak, D. F. Wong, S. M. Resnick, J. L. Prince, "Temporal trajectory and progression score estimation from voxelwise longitudinal imaging measures: Application to amyloid imaging", Information Processing in Medical Imaging (IPMI 2015), Isle of Skye, Scotland, June 28-July 3, 2015. (doi)
• M. Bilgel, A. Carass, S. M. Resnick, D. F. Wong, J. L. Prince, "Deformation Field Correction for Spatial Normalization of PET Images Using a Population-Derived Partial Least Squares Model", Machine Learning in Medical Imaging (MLMI 2014), Boston, MA, September 14, 2014. (doi)
• M. Bilgel, S. Roy, A. Carass, P. A. Nyquist, J. L. Prince, "Automated Anatomical Labeling of Cerebrovascular Networks", Proceedings of SPIE Medical Imaging (SPIE-MI 2013), Orlando, FL, February 9-14, 2013. (doi) Oral presentation.

Conference Abstracts

• M. Bilgel, Y. An, Y. Zhou, D. F. Wong, J. L. Prince, S. M. Resnick, "Age at onset of amyloid accumulation in relation to APOE genotype", Alzheimer’s Association International Conference (AAIC 2015), Washington, DC, July 19-23, 2015. Oral presentation.
• C. A. Fredericks, V. E. Sturm, A. Hua, M. Bilgel, D. F. Wong, S. M. Resnick, W. W. Seeley, "Neuroticism increases with age in cognitively normal older adults who are PiB positive", American Academy of Neurology 67th Annual Meeting (AAN 2015), Washington, DC, April 18-25, 2015.
• M. Bilgel, Y. An, Y. Zhou, D. F. Wong, J. Prince, S. M. Resnick, "APOE ε4 allele is associated with an earlier onset of amyloid deposition", Human Amyloid Imaging Conference (HAI 2015), Miami, FL, January 14-16, 2015. Oral presentation.
• M. Bilgel, S. M. Resnick, D. F. Wong, B. Jedynak, J. Prince, "Temporal progression of cerebral amyloid deposition as measured by 11C-PiB PET imaging", Human Amyloid Imaging Conference (HAI 2015), Miami, FL, January 14-16, 2015.
• P. A. Nyquist, M. Bilgel, L. R. Yanek, T. F. Moy, L. C. Becker, J. Cuzzocreo, D. M. Yousem, D. M. Becker, B. G. Kral, D. Vaidya, "Age Associated Atrophy is More Closely Correlated to Periventricular than Deep White Matter Disease", International Stroke Conference (ISC 2014), San Diego, CA, February 12-14, 2014.
• P. A. Nyquist, L. R. Yanek, M. Bilgel, J. Cuzzocreo, L. C. Becker, K. Chevalier, T. Woessner, D. M. Becker, "Manipulative Dexterity is Associated with Occult White Matter Ischemic Lesions in Healthy Asymptomatic Persons at Increased Risk for Cardiovascular Disease", International Stroke Conference (ISC 2014), San Diego, CA, February 12-14, 2014.
• P. A. Nyquist, C. Talbot, M. Bilgel, L. R. Yanek, L. C. Becker, J. Cuzzocreo, R. Mathias, A. Berger, C. Cheadle, D. M. Becker, "Increased Activation of Inflammatory Genes in Monocytes of Healthy People with Ischemic White Matter Disease", International Stroke Conference (ISC 2014), San Diego, CA, February 12-14, 2014.
• M. Bilgel, Y. Chuang, Y. An, J. Prince, D. F. Wong, M. Thambisetty, S. M. Resnick, "Body mass index is associated with verbal episodic memory in cognitively normal older individuals with low fibrillar amyloid-beta measured by [11C]-PiB", Human Amyloid Imaging Conference (HAI 2014), Miami, FL, January 15-17, 2014.
• S. M. Resnick, M. Bilgel, Y. An, M. Thambisetty, M. A. Kraut, Y. Zhou, D. F. Wong, "Longitudinal change in amyloid deposition, measured by PET and 11-C-PiB in nondemented older adults", American College of Neuropsychopharmacology (ACNP 2013), Hollywood, FL, December 8-12, 2013.
• M. Bilgel, Y. An, A. Lang, J. Prince, B. Jedynak, S. M. Resnick, "Temporal Sequence of Alzheimer’s Disease-Related Cognitive Biomarker Changes in the Baltimore Longitudinal Study of Aging", Alzheimer’s Association International Conference (AAIC 2013), Boston, MA, July 13-18, 2013.
• A. P. Spira, A. A. Gamaldo, Y. An, M. N. Wu, E. M. Simonsick, M. Bilgel, Y. Zhou, D. F. Wong, L. Ferrucci, S. M. Resnick, "Subjective Sleep Indices and Neuroimaging Evidence of β-Amyloid Deposition in Older Adults", 27th Annual Meeting of the Associated Professional Sleep Societies (SLEEP 2013), Baltimore, MD, June 1-5, 2013.
• P. Nyquist, L. Yanek, D. Vaidya, R. Gottesman, B. Kral, M. Bilgel, J. Cuzzocreo, J. Prince, L. Becker, D. Becker, "Extreme White Matter Hyperintensity Volumes are More Prevalent in African Americans in a Cohort at Risk for Vascular Disease", American Academy of Neurology 65th Annual Meeting, San Diego, CA, March 16-23, 2013.
• P. A. Nyquist, M. Bilgel, L. R. Yanek, T. F. Moy, B. G. Kral, D. M. Becker, L. C. Becker, D. Vaidya, "The Distribution of White Matter Hyperintensities by Age in Persons with Familial Cardiovascular Risk", International Stroke Conference (ISC 2013), Honolulu, HI, February 6-8, 2013. Moderated poster.
• M. Bilgel, J. L. Cuzzocreo, L. C. Becker, D. M. Becker, J. L. Prince, P. A. Nyquist, "Spatial Characterization of Deep White Matter Hyperintensities Seen on Brain MR Images in Asymptomatic Persons with a Family History of Early-Onset Coronary Artery Disease", Johns Hopkins University School of Medicine 3rd Annual Cardiovascular Research Retreat, Baltimore, MD, June 1, 2012.

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