Difference between revisions of "Clinical Trials"
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{{iacl-pub | author = S. Wang, A. Carass, S.F. Maroufi, J. Hua, J.L. Prince, M.G. Luciano, and on behalf of the PENS investigators | title = Methodological Analysis of the PENS Trial: An Automatic Pipeline for Calculating Evan’s Index and Callosal Angle for NPH | conf = hwc2026}} | {{iacl-pub | author = S. Wang, A. Carass, S.F. Maroufi, J. Hua, J.L. Prince, M.G. Luciano, and on behalf of the PENS investigators | title = Methodological Analysis of the PENS Trial: An Automatic Pipeline for Calculating Evan’s Index and Callosal Angle for NPH | conf = hwc2026}} | ||
{{iacl-pub | author = S. Wang, A. Carass, S.F. Maroufi, J. Hua, J.L. Prince, M.G. Luciano, and on behalf of the PENS investigators | title = Mitigating Valve Artifacts in Post-Shunt Surgery MRI of the PENS Trial Using a 3D Diffusion Model | conf = hwc2026}} | {{iacl-pub | author = S. Wang, A. Carass, S.F. Maroufi, J. Hua, J.L. Prince, M.G. Luciano, and on behalf of the PENS investigators | title = Mitigating Valve Artifacts in Post-Shunt Surgery MRI of the PENS Trial Using a 3D Diffusion Model | conf = hwc2026}} | ||
| − | {{iacl-pub| author = S. Wang, S. Wei, S.W. Remedios, J. Zhang, B. E. Dewey, A.M. Blitz, M.G. Luciano, A. Carass, and J.L. Prince | title = VAID: Valve artifact inpainting for normal pressure hydrocephalus from a 3D MRI diffusion model| conf = isbi2026 | doi = 10.1109/ISBI61048.2026.11515475}} | + | {{iacl-pub | author = S. Wang, S. Wei, S.W. Remedios, J. Zhang, B. E. Dewey, A.M. Blitz, M.G. Luciano, A. Carass, and J.L. Prince | title = VAID: Valve artifact inpainting for normal pressure hydrocephalus from a 3D MRI diffusion model| conf = isbi2026 | doi = 10.1109/ISBI61048.2026.11515475}} |
| + | {{iacl-pub | author = M.G. Luciano, M.A. Williams, M.G. Hamilton, H.L. Katzen, N.A. Dasher, A. Moghekar, J. Hua, J. Malm, A. Eklund, N.A. Abel, A.M. Raslan, B.D. Elder, J.J. Savage, D.L. Barrow, K. Shahlaie, H. Jensen, T.J. Zwimpfer, J. Wollett, D.F. Hanley, and R. Holubkov, for the PENS Trial Investigators and the Adult Hydrocephalus Clinical Research Network | title = A Randomized Trial of Shunting for Idiopathic Normal-Pressure Hydrocephalus | jrnl = nejm | number = 393(22):2198-2209 | when = 2025 | doi = 10.1056/NEJMoa2503109}} | ||
Revision as of 03:17, 16 September 2026
Clinical Trials
PENS NPH Shunting Trial
The Placebo-Controlled Efficacy in Idiopathic Normal Pressure Hydrocephalus (iNPH) Shunting (PENS) trial is a multi-center blinded, randomized, placebo-controlled design investigation of cerebrospinal fluid (CSF) shunt surgery to study the shunt efficacy in iNPH patients.
ClinicalTrials.gov Identifier: NCT05081128
Associated Publications
- S. Wang, A. Carass, S.F. Maroufi, J. Hua, J.L. Prince, M.G. Luciano, and on behalf of the PENS investigators, "Methodological Analysis of the PENS Trial: An Automatic Pipeline for Measuring Corpus Callosum Arching", Hydrocephalus 2026 World Congress, São Paulo, Brazil, July 31 – August 3, 2026.
- S. Wang, A. Carass, S.F. Maroufi, J. Hua, J.L. Prince, M.G. Luciano, and on behalf of the PENS investigators, "Longitudinal Changes in Periventricular Lesion Volume are Associated with Ventricular Morphology Changes in Normal Pressure Hydrocephalus of the PENS Trial", Hydrocephalus 2026 World Congress, São Paulo, Brazil, July 31 – August 3, 2026.
- S. Wang, A. Carass, S.F. Maroufi, J. Hua, J.L. Prince, M.G. Luciano, and on behalf of the PENS investigators, "Methodological Analysis of the PENS Trial: An Automatic Pipeline for Calculating Evan’s Index and Callosal Angle for NPH", Hydrocephalus 2026 World Congress, São Paulo, Brazil, July 31 – August 3, 2026.
- S. Wang, A. Carass, S.F. Maroufi, J. Hua, J.L. Prince, M.G. Luciano, and on behalf of the PENS investigators, "Mitigating Valve Artifacts in Post-Shunt Surgery MRI of the PENS Trial Using a 3D Diffusion Model", Hydrocephalus 2026 World Congress, São Paulo, Brazil, July 31 – August 3, 2026.
- S. Wang, S. Wei, S.W. Remedios, J. Zhang, B. E. Dewey, A.M. Blitz, M.G. Luciano, A. Carass, and J.L. Prince, "VAID: Valve artifact inpainting for normal pressure hydrocephalus from a 3D MRI diffusion model", 23rd IEEE International Symposium on Biomedical Imaging (ISBI 2026), London, UK, April 8–11, 2026.
- M.G. Luciano, M.A. Williams, M.G. Hamilton, H.L. Katzen, N.A. Dasher, A. Moghekar, J. Hua, J. Malm, A. Eklund, N.A. Abel, A.M. Raslan, B.D. Elder, J.J. Savage, D.L. Barrow, K. Shahlaie, H. Jensen, T.J. Zwimpfer, J. Wollett, D.F. Hanley, and R. Holubkov, for the PENS Trial Investigators and the Adult Hydrocephalus Clinical Research Network, "A Randomized Trial of Shunting for Idiopathic Normal-Pressure Hydrocephalus", N Engl J Med, 393(22):2198-2209, 2025.
