Clinical Trials

Clinical Trials

PENS NPH Shunting Trial

The Placebo-Controlled Efficacy in Idiopathic Normal Pressure Hydrocephalus (iNPH) Shunting (PENS) trial is a multi-center blinded, randomized, placebo-controlled design investigation of cerebrospinal fluid (CSF) shunt surgery to study the shunt efficacy in iNPH patients.

ClinicalTrials.gov Identifier: NCT05081128

Associated Publications

• S. Wang, A. Carass, S.F. Maroufi, J. Hua, J.L. Prince, M.G. Luciano, and on behalf of the PENS investigators, "Methodological Analysis of the PENS Trial: An Automatic Pipeline for Measuring Corpus Callosum Arching", Hydrocephalus 2026 World Congress, São Paulo, Brazil, July 31 – August 3, 2026.
• S. Wang, A. Carass, S.F. Maroufi, J. Hua, J.L. Prince, M.G. Luciano, and on behalf of the PENS investigators, "Longitudinal Changes in Periventricular Lesion Volume are Associated with Ventricular Morphology Changes in Normal Pressure Hydrocephalus of the PENS Trial", Hydrocephalus 2026 World Congress, São Paulo, Brazil, July 31 – August 3, 2026.
• S. Wang, A. Carass, S.F. Maroufi, J. Hua, J.L. Prince, M.G. Luciano, and on behalf of the PENS investigators, "Methodological Analysis of the PENS Trial: An Automatic Pipeline for Calculating Evan’s Index and Callosal Angle for NPH", Hydrocephalus 2026 World Congress, São Paulo, Brazil, July 31 – August 3, 2026.
• S. Wang, A. Carass, S.F. Maroufi, J. Hua, J.L. Prince, M.G. Luciano, and on behalf of the PENS investigators, "Mitigating Valve Artifacts in Post-Shunt Surgery MRI of the PENS Trial Using a 3D Diffusion Model", Hydrocephalus 2026 World Congress, São Paulo, Brazil, July 31 – August 3, 2026.
• S. Wang, S. Wei, S.W. Remedios, J. Zhang, B. E. Dewey, A.M. Blitz, M.G. Luciano, A. Carass, and J.L. Prince, "VAID: Valve artifact inpainting for normal pressure hydrocephalus from a 3D MRI diffusion model", 23^rd IEEE International Symposium on Biomedical Imaging (ISBI 2026), London, UK, April 8–11, 2026.